Neurotoxicity Assessment of Four Different Pesticides Using In Vitro Enzymatic Inhibition Assays.

ABSTRACT: Pesticides affect different organs and tissues according to their bioavailability, chemical properties and further molecular interactions. In animal models exposed to several classes of pesticides, neurotoxic effects have been described, including the reduction of acetylcholinesterase activity in tissue homogenates. However, in homogenates, the reduction in enzymatic activity may also result from lower enzymatic expression and not only from enzymatic inhibition. Thus, in this work, we aimed to investigate the neurotoxic potential of four distinct pesticides: glyphosate (herbicide), imazalil (fungicide), imidacloprid (neonicotinoid insecticide) and lambda-cyhalothrin (pyrethroid insecticide), by assessing their inhibitory effect on the activity of acetylcholinesterase (AChE), butyrylcholine

SUBMITTER: Martins-Gomes C 

PROVIDER: S-EPMC9413506 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature