Comprehensive analysis of androgen receptor status in prostate cancer with neuroendocrine differentiation.

ABSTRACT: The androgen receptor (AR) signaling is a key contributor to tumorigenesis and the progression of prostate cancer. A subset of patients may develop neuroendocrine (NE) features, resulting in resistance to androgen deprivation therapy and poor prognosis. In this study, we combined immunostaining and bulk and single-cell transcriptome analyses to better characterize the status of AR in prostate cancer with neuroendocrine differentiation. The exploration of online datasets indicated the existence of AR^HIGH/NE^HIGH prostate cancer and revealed that these double-high cases are majorly present in castration-resistant prostate cancer with a less neuroendocrine-transdifferentiated state. We then reviewed 8,194 prostate cancer cases with available immunohistochemistry reports a

SUBMITTER: Su R 

PROVIDER: S-EPMC9413533 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature