FBXO17 Inhibits the Wnt/β-Catenin Pathway and Proliferation of Ishikawa Cells.

ABSTRACT: Uterine corpus endometrial carcinoma (UCEC) is one of the most common types of cancer in women, and the incidence is rapidly increasing. Studies have shown that various signaling pathways serve crucial roles in the tumorigenesis of UCEC, amongst which the Wnt/β-catenin pathway is of great interest due to its crucial role in cell proliferation and the huge potential as a therapeutic target. In the present study, it was shown that FBXO17, which is a member of the F-box family, is abnormally downregulated in UCEC tissues compared with non-tumor endometrial tissues, and this was significantly associated with the clinical histological grade, as well as the abnormal proliferation of the UCEC cell line, Ishikawa, both in vitro and in vivo. Besides, the results suggested that FBXO17

SUBMITTER: Zheng ZM 

PROVIDER: S-EPMC9413558 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature