The Relative Positioning of B and T Cell Epitopes Drives Immunodominance.

ABSTRACT: Humoral immunity is crucial for protection against invading pathogens. Broadly neutralizing antibodies (bnAbs) provide sterilizing immunity by targeting conserved regions of viral variants and represent the goal of most vaccination approaches. While antibodies can be selected to bind virtually any region of a given antigen, the consistent induction of bnAbs in the context of influenza and HIV has represented a major roadblock. Many possible explanations have been considered; however, none of the arguments proposed to date seem to fully recapitulate the observed counter-selection for broadly protective antibodies. Antibodies can influence antigen presentation by enhancing the processing of CD4 epitopes adjacent to the binding region while suppressing the overlapping ones. We analyze the rel

SUBMITTER: Biavasco R 

PROVIDER: S-EPMC9413633 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature