Risk Factors Associated with Post-Acute Sequelae of SARS-CoV-2 in an EHR Cohort: A National COVID Cohort Collaborative (N3C) Analysis as part of the NIH RECOVER program.

ABSTRACT:

Background

More than one-third of individuals experience post-acute sequelae of SARS-CoV-2 infection (PASC, which includes long-COVID).

Objective

To identify risk factors associated with PASC/long-COVID.

Design

Retrospective case-control study.

Setting

31 health systems in the United States from the National COVID Cohort Collaborative (N3C).

Patients

8,325 individuals with PASC (defined by the presence of the International Classification of Diseases, version 10 code U09.9 or a long-COVID clinic visit) matched to 41,625 controls within the same health system.

Measurements

Risk factors included demographics, comorbidities, and treatment and acute characteristics related to COVID-19. Multivariable logistic regression, random forest, and XGBoost were

SUBMITTER: Hill E 

PROVIDER: S-EPMC9413724 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature