ASFV Gene A151R Is Involved in the Process of Virulence in Domestic Swine.

ABSTRACT: African swine fever virus (ASFV) is the etiological agent of a swine pandemic affecting a large geographical area extending from Central Europe to Asia. The viral disease was also recently identified in the Dominican Republic and Haiti. ASFV is a structurally complex virus with a large dsDNA genome that encodes for more than 150 genes. Most of these genes have not been experimentally characterized. One of these genes, A151R, encodes for a nonstructural protein and has been reported to be required for the replication of a Vero-cell-adapted ASFV strain. Here, we evaluated the role of the A151R gene in the context of the highly virulent field isolate Georgia 2010 (ASFV-G) during virus replication in swine macrophage cell cultures and during experimental infection in swine. We show that the re

SUBMITTER: Ramirez-Medina E 

PROVIDER: S-EPMC9413758 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature