Assessing whether genetic scores explain extra variation in birthweight, when added to clinical and anthropometric measures.

ABSTRACT:

Background

Human birthweight is a complex, multifactorial trait. Maternal characteristics contribute to birthweight variation by influencing the intrauterine environment. Variation explained by genetic effects is also important, but their contributions have not been assessed alongside other key determinants. We aimed to investigate variance in birthweight explained by genetic scores in addition to easily-measurable clinical and anthropometric variables.

Methods

We analysed 549 European-ancestry parent-offspring trios from a UK community-based birth cohort. We investigated variance explained in birthweight (adjusted for sex and gestational age) in multivariable linear regression models including genetic scores, routinely-measured maternal characteristics, and parental anthrop

SUBMITTER: Haulder M 

PROVIDER: S-EPMC9414111 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature