Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation.

ABSTRACT:

Background

Probiotic use in preterm infants can mitigate the impact of antibiotic exposure and reduce rates of certain illnesses; however, the benefit on the gut resistome, the collection of antibiotic resistance genes, requires further investigation. We hypothesized that probiotic supplementation of early preterm infants (born < 32-week gestation) while in hospital reduces the prevalence of antibiotic resistance genes associated with pathogenic bacteria in the gut. We used a targeted capture approach to compare the resistome from stool samples collected at the term corrected age of 40 weeks for two groups of preterm infants (those that routinely received a multi-strain probiotic during hospitalization and those that did not) with samples from full-term infants at 10 days of age to

SUBMITTER: Guitor AK 

PROVIDER: S-EPMC9414150 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature