Identification of Immunogenic MHC Class II Human HER3 Peptides that Mediate Anti-HER3 CD4⁺ Th1 Responses and Potential Use as a Cancer Vaccine.

ABSTRACT: The HER3/ERBB3 receptor is an oncogenic receptor tyrosine kinase that forms heterodimers with EGFR family members and is overexpressed in numerous cancers. HER3 overexpression associates with reduced survival and acquired resistance to targeted therapies, making it a potential therapeutic target in multiple cancer types. Here, we report on immunogenic, promiscuous MHC class II-binding HER3 peptides, which can generate HER3-specific CD4⁺ Th1 antitumor immune responses. Using an overlapping peptide screening methodology, we identified nine MHC class II-binding HER3 epitopes that elicited specific Th1 immune response in both healthy donors and breast cancer patients. Most of these peptides were not identified by current binding algorithms. Homology assessment of amino acid sequence

SUBMITTER: Basu A 

PROVIDER: S-EPMC9414303 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature