Bacopa Protects against Neurotoxicity Induced by MPP⁺ and Methamphetamine.

ABSTRACT: The neurotoxins methamphetamine (METH) and 1-methyl-4-phenylpyridinium (MPP⁺) damage catecholamine neurons. Although sharing the same mechanism to enter within these neurons, METH neurotoxicity mostly depends on oxidative species, while MPP⁺ toxicity depends on the inhibition of mitochondrial activity. This explains why only a few compounds protect against both neurotoxins. Identifying a final common pathway that is shared by these neurotoxins is key to prompting novel remedies for spontaneous neurodegeneration. In the present study we assessed whether natural extracts from Bacopa monnieri (BM) may provide a dual protection against METH- and MPP⁺-induced cell damage as measured by light and electron microscopy. The protection induced by BM against ca

SUBMITTER: Ferrucci M 

PROVIDER: S-EPMC9414486 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature