Bee Venom Induces Acute Inflammation through a H₂O₂-Mediated System That Utilizes Superoxide Dismutase.

ABSTRACT: Venoms from venomous arthropods, including bees, typically induce an immediate local inflammatory response; however, how venoms acutely elicit inflammatory response and which components induce an inflammatory response remain unknown. Moreover, the presence of superoxide dismutase (SOD3) in venom and its functional link to the acute inflammatory response has not been determined to date. Here, we confirmed that SOD3 in bee venom (bvSOD3) acts as an inducer of H₂O₂ production to promote acute inflammatory responses. In mouse models, exogenous bvSOD3 rapidly induced H₂O₂ overproduction through superoxides that are endogenously produced by melittin and phospholipase A₂, which then upregulated caspase-1 activation and proinflammatory molecul

SUBMITTER: Lee KS 

PROVIDER: S-EPMC9414663 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature