Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC9415068 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Liu Xianping X Chen Yixin Y Geng Daoying D Li Haichun H Jiang Ting T Luo Zimiao Z Wang Jianhong J Pang Zhiqing Z Zhang Jun J
Membranes 20220729 8
Biomimetic drug delivery systems, especially red blood cell (RBC) membrane-based nanoparticle drug delivery systems (RNP), have been extensively utilized in tumor drug delivery because of their excellent biocompatibility and prolonged circulation. In this study, we developed an active targeting pH-sensitive RNP loaded with DOX by decorating an aptamer SL1 on RBC membranes (SL1-RNP-DOX) for c-Met-targeted therapy of glioblastoma multiforme (GBM). SL1 could specifically bind to c-Met, which is hig ...[more]