NPvis: An Interactive Visualizer of Peptidic Natural Product-MS/MS Matches.

ABSTRACT: Peptidic natural products (PNPs) represent a medically important class of secondary metabolites that includes antibiotics, anti-inflammatory and antitumor agents. Advances in tandem mass spectra (MS/MS) acquisition and in silico database search methods have enabled high-throughput PNP discovery. However, the resulting spectra annotations are often error-prone and their validation remains a bottleneck. Here, we present NPvis, a visualizer suitable for the evaluation of PNP-MS/MS matches. The tool interactively maps annotated spectrum peaks to the corresponding PNP fragments and allows researchers to assess the match correctness. NPvis accounts for the wide chemical diversity of PNPs that prevents the use of the existing proteomics visualizers. Moreover, NPvis works even if the exact chemica

SUBMITTER: Kunyavskaya O 

PROVIDER: S-EPMC9415073 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature