Changes in structural brain development after selective fetal growth restriction in monochorionic twins.

ABSTRACT:

Objectives

Fetal growth restriction (FGR) may alter brain development permanently, resulting in lifelong structural and functional changes. However, in studies addressing this research question, FGR singletons have been compared primarily to matched appropriately grown singletons, a design which is inherently biased by differences in genetic and maternal factors. To overcome these limitations, we conducted a within-pair comparison of neonatal structural cerebral ultrasound measurements in monochorionic twin pairs with selective FGR (sFGR).

Methods

Structural cerebral measurements on neonatal cerebral ultrasound were compared between the smaller and larger twins of monochorionic twin pairs with sFGR, defined as a birth-weight discordance (BWD) ≥ 20%, born in our center betwee

SUBMITTER: Groene SG 

PROVIDER: S-EPMC9415097 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature