Understanding the inter-relationships of type 2 diabetes and hypertension with brain and cognitive health: A UK Biobank study.

ABSTRACT:

Aim

To understand the impact of diabetes and co-morbid hypertension on cognitive and brain health.

Materials and methods

We used data from the UK Biobank cohort consisting of ~500 000 individuals aged 40 to 69 years. Our outcomes included brain structural magnetic resonance imaging variables and cognitive function tests in a maximum of 38 918 individuals. We firstly tested associations with all outcomes between those with diabetes (n = 2043) and without (n = 36 875) and, secondly, compared those with co-morbid diabetes/hypertension (n = 1283) with those with only diabetes (n = 760), hypertension (n = 9649) and neither disease (n = 27 226). Our analytical approach comprised linear regression models, with adjustment for a range of demographic and health factors. Standardized b

SUBMITTER: Newby D 

PROVIDER: S-EPMC9415107 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature