Pseudoreplication in genomic-scale data sets.

ABSTRACT: In genomic-scale data sets, loci are closely packed within chromosomes and hence provide correlated information. Averaging across loci as if they were independent creates pseudoreplication, which reduces the effective degrees of freedom (df') compared to the nominal degrees of freedom, df. This issue has been known for some time, but consequences have not been systematically quantified across the entire genome. Here, we measured pseudoreplication (quantified by the ratio df'/df) for a common metric of genetic differentiation (F_ST ) and a common measure of linkage disequilibrium between pairs of loci (r² ). Based on data simulated using models (SLiM and msprime) that allow efficient forward-in-time and coalescent simulations while precisely controlling population pedig

SUBMITTER: Waples RS 

PROVIDER: S-EPMC9415146 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature