Piceatannol Alleviates Clostridium perfringens Virulence by Inhibiting Perfringolysin O.

ABSTRACT: Clostridium perfringens (C. perfringens) is an important foodborne pathogen that can cause diseases such as gas gangrene and necrotizing enteritis in a variety of economic animals, seriously affecting public health and the economic benefits and healthy development of the livestock and poultry breeding industry. Perfringolysin O (PFO) is an important virulence factor of C. perfringens and plays critical roles in necrotic enteritis and gas gangrene, rendering it an ideal target for developing new drugs against infections caused by this pathogen. In this study, based on biological activity inhibition assays, oligomerization tests and computational biology assays, we found that the foodborne natural component piceatannol reduced pore-forming activity with an inhibitory rat

SUBMITTER: Wang G 

PROVIDER: S-EPMC9415171 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature