Long Non-Coding RNAs: The New Frontier into Understanding the Etiology of Alcohol Use Disorder.

ABSTRACT: Alcohol use disorder (AUD) is a complex, chronic, debilitating condition impacting millions worldwide. Genetic, environmental, and epigenetic factors are known to contribute to the development of AUD. Long non-coding RNAs (lncRNAs) are a class of regulatory RNAs, commonly referred to as the "dark matter" of the genome, with little to no protein-coding potential. LncRNAs have been implicated in numerous processes critical for cell survival, suggesting that they play important functional roles in regulating different cell processes. LncRNAs were also shown to display higher tissue specificity than protein-coding genes and have a higher abundance in the brain and central nervous system, demonstrating a possible role in the etiology of psychiatric disorders. Indeed, genetic (e.g., genome-wide

SUBMITTER: Denham AN 

PROVIDER: S-EPMC9415279 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature