Changes in Body Mass Index after Initiation of Antiretroviral Treatment: Differences by Class of Core Drug.

ABSTRACT: Recent research on antiretroviral treatment (ART) for HIV suggests that integrase strand transfer inhibitors (INSTIs) cause faster weight gain compared to other drug classes. Here, we investigated changes in body mass index (BMI) and obesity prevalence after treatment initiation and corresponding differences between drug classes. Data were derived from a large collaborative cohort in Greece. Included individuals were adults who started ART, in or after 2010, while previously ART naïve and achieved virologic response within the first year of ART. Data were analysed using mixed fractional polynomial models. INSTI regimens led to the more pronounced BMI increases, followed by boosted PI and NNRTI based regimens. Individuals with normal initial BMI are expected to gain 6 kg with an INSTI regim

SUBMITTER: Pantazis N 

PROVIDER: S-EPMC9415309 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature