IHNV Infection Induces Strong Mucosal Immunity and Changes of Microbiota in Trout Intestine.

ABSTRACT: The fish intestinal mucosa is among the main sites through which environmental microorganisms interact with the host. Therefore, this tissue not only constitutes the first line of defense against pathogenic microorganisms but also plays a crucial role in commensal colonization. The interaction between the mucosal immune system, commensal microbiota, and viral pathogens has been extensively described in the mammalian intestine. However, very few studies have characterized these interactions in early vertebrates such as teleosts. In this study, rainbow trout (Oncorhynchus mykiss) was infected with infectious hematopoietic necrosis virus (IHNV) via a recently developed immersion method to explore the effects of viral infection on gut immunity and microbial community structure. IHNV suc

SUBMITTER: Huang Z 

PROVIDER: S-EPMC9415333 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature