Identification of cancer risk assessment signature in patients with chronic obstructive pulmonary disease and exploration of the potential key genes.

ABSTRACT: It is essential to assess the cancer risk for patients with chronic obstructive pulmonary disease (COPD). Comparing gene expression data from patients with lung cancer (a total of 506 samples) and those with cancer-adjacent normal lung tissues (a total of 370 samples), we generated a qualitative transcriptional signature consisting of 2046 gene pairs. The signature was verified in an evaluation dataset comprising 18 subjects with severe disease and 52 subjects with moderate disease (Wilcoxon rank-sum test; p = 7.33 × 10^-5). Similar results were obtained in other independent datasets. Among the gene pairs in the signature, 326 COPD stage-related gene pairs were identified based on Spearman's rank correlation tests and those gene pairs comprised 368 unique genes. Of these 3

SUBMITTER: Guan Q 

PROVIDER: S-EPMC9415445 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature