Ionophore Antibiotics Inhibit Type II Feline Coronavirus Proliferation In Vitro.

ABSTRACT: Feline coronaviruses (FCoVs) infect cats worldwide and cause severe systemic diseases, such as feline infectious peritonitis (FIP). FIP has a high mortality rate, and drugs approved by the Food and Drug Administration have been ineffective for the treatment of FIP. Investigating host factors and the functions required for FCoV replication is necessary to develop effective drugs for the treatment of FIP. FCoV utilizes an endosomal trafficking system for cellular entry after binding between the viral spike (S) protein and its receptor. The cellular enzymes that cleave the S protein of FCoV to release the viral genome into the cytosol require an acidic pH optimized in the endosomes by regulating cellular ion concentrations. Ionophore antibiotics are compounds that form complexes with alkali i

SUBMITTER: Tanaka Y 

PROVIDER: S-EPMC9415497 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature