SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers.

ABSTRACT:

Background

The research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort of more than 60,000 health workers.

Methods

A multicentric retrospective cohort study, involving 12 European centers, was carried out within the ORCHESTRA project, collecting data up to 18 November 2021 on fully vaccinated health workers. The cumulative incidence of SARS-CoV-2 breakthrough infections was investigated with its association with occupational and social-demographic characteristics (age, sex, job title, previous SARS-CoV-2 infection, antibody titer levels, and time from the vaccination course completion).

Results

Among 64,172 health workers from 12 European health centers, 797 breakthrough infections were observ

SUBMITTER: Porru S 

PROVIDER: S-EPMC9415790 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature