Screening for severe drug-drug interactions in patients with multiple sclerosis: A comparison of three drug interaction databases.

ABSTRACT: Background: Patients with multiple sclerosis (MS) often undergo complex treatment regimens, resulting in an increased risk of polypharmacy and potential drug-drug interactions (pDDIs). Drug interaction databases are useful for identifying pDDIs to support safer medication use. Objective: To compare three different screening tools regarding the detection and classification of pDDIs in a cohort of MS patients. Furthermore, we aimed at ascertaining sociodemographic and clinical factors that are associated with the occurrence of severe pDDIs. Methods: The databases Stockley's, Drugs.com and MediQ were used to identify pDDIs by screening the medication schedules of 627 patients. We determined the overlap of the identified pDDIs and the level of agreement in pDDI severity ra

SUBMITTER: Hecker M 

PROVIDER: S-EPMC9416235 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature