Macrolides from Streptomyces sp. SN5452 and Their Antifungal Activity against Pyricularia oryzae.

ABSTRACT: Pyricularia oryzae causes rice blast, the major destructive disease in nearly all rice fields. In order to obtain highly active compounds against P. oryzae, four new 20-membered macrolides named venturicidins G-J (1-4) were isolated from the culture broth of Streptomyces sp. SN5452 along with two known ones, venturicidins A (5) and B (6). Their structures were determined by the cumulative analyses of nuclear magnetic resonance (NMR) spectroscopy and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. All isolated compounds were evaluated for their antifungal activity against P. oryzae. Interestingly, these compounds exhibited obvious inhibition to mycelial growth and conidial germination of P. oryzae. Remarkably,

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9416504 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature