HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men.

ABSTRACT:

Objective

CMV coinfection contributes to sustained immune activation in people with chronic HIV. In particular, asymptomatic CMV shedding in semen has been associated with increased local and systemic immune activation, even during suppressive antiretroviral therapy (ART). However, the effect of seminal CMV shedding in people with HIV in the earliest phase of HIV infection is not known.

Methods

Using Luminex, we measured the concentration of 34 cytokines in the blood plasma of sixty-nine men who had sex with men with or without HIV and in subgroups of CMV shedders vs. non-shedders. Differences in blood plasma cytokines between groups were investigated using the multivariate supervised partial least squares discriminant analysis method.

Results

Independently of CMV, we

SUBMITTER: Vanpouille C 

PROVIDER: S-EPMC9416553 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature