Optimization of Precursor Synthesis Conditions of (2S,4S)4-[¹⁸F]FPArg and Its Application in Glioma Imaging.

ABSTRACT: Although the tracer (2S,4S)4-[¹⁸F]FPArg is expected to provide a powerful imaging method for the diagnosis and treatment of clinical tumors, it has not been realized due to the low yield of chemical synthesis and radiolabeling. A simple synthetic method for the radiolabeled precursor of (2S,4S)4-[¹⁸F]FPArg in stable yield was obtained by adjusting the sequence of the synthetic steps. Furthermore, the biodistribution experiments confirmed that (2S,4S)4-[¹⁸F]FPArg could be cleared out quickly in wild type mouse. Cell uptake experiments and U87MG tumor mouse microPET-CT imaging experiments showed that the tumor had high uptake of (2S,4S)4-[¹⁸F]FPArg and the clearance was slow, but (2S,4S)4-[¹⁸F]FPArg was rapidly cleared in normal brain ti

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9416586 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature