NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort.

ABSTRACT: Schizophrenia is a widespread mental disorder that leads to significant functional impairments and premature death. The state of the art indicates gaps in the understanding and diagnosis of this disease, but also the need for personalized and precise approaches to patients through customized medical treatment and reliable monitoring of treatment response. In order to fulfill existing gaps, the establishment of a universal set of disorder biomarkers is a necessary step. Metabolomic investigations of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39), based on NMR analyses associated with chemometrics, led to the identification of 26 metabolites/biomarkers for this disorder. Principal component analysis (PCA) and orthogonal partial least squares discriminant

SUBMITTER: Simic K 

PROVIDER: S-EPMC9416612 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature