Synergetic effects of thymoquinone-loaded porous PVPylated Fe₃O₄ nanostructures for efficient pH-dependent drug release and anticancer potential against triple-negative cancer cells.

ABSTRACT: Porous iron oxide nanostructures have attracted increasing attention due to their potential biomedical applications as nanocarriers for cancer and many other therapies as well as minimal toxicity. Herbal anti-cancer agent thymoquinone loaded on Fe₃O₄ nanoparticles is envisaged to offer solution towards cancer treatment. The purpose of the present study was to investigate the efficacy of thymoquinone-loaded PVPylated Fe₃O₄ magnetic nanoparticles (TQ-PVP-Fe₃O₄ NPs) against triple-negative breast cancer (TNBC) cells. The porous PVPylated Fe₃O₄ NPs were prepared by a simple solvothermal process, whereas the thymoquinone drug was loaded via the nanoprecipitation method. Fourier transform infrared (FTI

SUBMITTER: Kumar SR 

PROVIDER: S-EPMC9416817 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature