Prognostic features of endometrial cancer metastasis to the central nervous system.

ABSTRACT:

Objectives

Central nervous system metastases (CNSm) secondary to endometrial cancer (EC) are rare. As a result, prognostic factors for this patient population are not well described.

Methods

EC patients with CNSm were identified retrospectively from two academic centers. EC patients without CNSm (non-CNSm) were used as controls. Chi-square and Fisher's exact tests were used for analysis of categorial variables. Wilcoxon tests were used for quantitative measures. Overall survival (OS) was compared with Log-rank test. Cox proportional hazard models were used to estimate hazard ratios for OS.

Results

22 EC patients with CNSm and 354 non-CNSm patients were included. Compared to non-CNSm EC, the CNSm cohort was younger (58.5 vs 62.0 years, p = 0.018) with lower BMI (27.7 v

SUBMITTER: Kuznicki ML 

PROVIDER: S-EPMC9417007 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature