Ontology highlight
ABSTRACT:
SUBMITTER: Bi Y
PROVIDER: S-EPMC9417067 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Bi Ying Y Wang Miao M Peng Lirong L Ruan Lifo L Zhou Mengxue M Hu Yi Y Chen Jun J Gao Jimin J
Nanoscale advances 20191217 1
Tumor penetration of nanocarriers is still an unresolved challenge for effective drug delivery. Herein, we described a size-switchable nanoplatform in response to an external near-infrared (NIR) laser for transcellular drug delivery. The nanoplatform was constructed with a poly(<i>N</i>-isopropylacrylamide) (PNIPAM)-based nanogel encapsulating chitosan-coated single-walled carbon nanotubes, followed by loading a chemotherapeutic drug, doxorubicin (DOX). In mice bearing orthotopic breast tumors, ...[more]