Systemic Inflammation Is Associated With Future Risk of Fatal Infection: An Observational Cohort Study.

ABSTRACT:

Background

Many diseases are associated with chronic inflammation, resulting in widening application of anti-inflammatory therapies. Although they are effective as disease-modifying agents, these anti-inflammatory therapies increase the risk of serious infection; however, it remains unknown whether chronic systemic inflammation per se is also associated with fatal infection.

Methods

Using serum C-reactive protein (CRP) data from 461 052 UK Biobank participants, we defined incidence rate ratios (IRRs) for death from infection, cardiovascular disease, or other causes and adjusted for comorbidities and the use of anti-inflammatory therapies.

Results

Systemic inflammation, defined as CRP ≥2 mg/L, was common in all comorbidities considered. After adjusting for confounding

SUBMITTER: Drozd M 

PROVIDER: S-EPMC9417123 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature