CBXs-related prognostic gene signature correlates with immune microenvironment in gastric cancer.

ABSTRACT:

Background

Chromobox (CBX) proteins are important Polycomb family proteins in the development of gastric cancer. Nonetheless, the relationship between CBXs and gastric cancer microenvironment remains unclear.

Methods

Multiple databases were used for the analysis of CBXs expression and clinical value in gastric cancer patients. A Cox regression analysis was used to evaluate the prognostic importance of CBXs. Thereafter, regression analysis of LASSO Cox was used to construct the prognostic model. Spearman's correlation between risk score and immune infiltration was analyzed using the McP-counter algorithm. A predicted nomogram was developed to predict the overall survival of gastric cancer patients after 1, 2, and 3 years.

Results

In contrast

SUBMITTER: Zhang YJ 

PROVIDER: S-EPMC9417237 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature