PH-responsive hollow Fe-gallic acid coordination polymer for multimodal synergistic-therapy and MRI of cancer.

ABSTRACT: Tumor-microenvironment (TME) responsive nanostructures are attractive for drug delivery in clinical cancer treatment. The coordination polymer Fe-gallic acid (Fe-GA) is one of the promising drug carriers due to its pH-response, good biocompatibility, and minimal side effects. However, the hollow nanostructures of Fe-GA have not been reported until now, which seriously limits the quantity of drug delivery. Herein, hollow Fe-GA nanospheres were prepared for the first time with bovine serum albumin (BSA) combination (denoted as Fe-GA/BSA) under mild reaction conditions. Then, the antitumor drug doxorubicin (DOX) was loaded in the hollow Fe-GA/BSA to obtain Fe-GA/BSA@DOX. A series of experiments in vitro and in vivo indicated that the Fe-GA/BSA@DOX could efficiently respond to TM

SUBMITTER: Liu C 

PROVIDER: S-EPMC9417272 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature