In situ embedding dual-Fe nanoparticles in synchronously generated carbon for the synergistic integration of magnetic resonance imaging and drug delivery.

ABSTRACT: In situ incorporating versatile magnetic iron nanoparticles into ordered mesoporous carbon (OMC) by means of synthetic methodology for functional integration is a great challenge. Inspired by the phenomenon of uniovular twins in nature, a homometallic [Fe₉(μ₃-O)₄(O₃PPh)₃(O₂CCMe₃)₁₃] ({Fe₉P₃}) cluster was synthesized and used as the ovulum to in situ produce dual-Fe nanoparticle (γ-Fe₂O₃ and Fe(PO₃)₃)-functionalized OMC (dual-Fe/OMC). In vitro magnetic resonance imaging (MRI) studies showed a longitudinal relaxation (r ₁) and transverse relaxation (r ₂) of 9.74 and 26.59 mM^-1

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9417305 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature