Au/NiFe₂O₄ nanoparticle-decorated graphene oxide nanosheets for electrochemical immunosensing of amyloid beta peptide.

ABSTRACT: In the present work, an electrochemical immunosensor has been fabricated for the detection of amyloid beta peptide (βA_1--42) based on a gold nanoparticle/nickel ferrite decorated graphene oxide-chitosan nanocomposite (Au/NiFe₂O₄@GO-Ch) modified glassy carbon electrode (GCE) as an effective sensing platform. βA_1-42 has been analyzed as a potential biomarker for its application in Alzheimer's disease monitoring. The combination of highly conducting Au and NiFe₂O₄ nanoparticles on two-dimensional GO nanosheets provides an excellent platform for sensitive and selective sensing applications. A miniaturized Au/NiFe₂O₄@GO-Ch/GCE immunosensor was prepared by immobilization of βA antibody onto Au//NiFe₂

SUBMITTER: Devi R 

PROVIDER: S-EPMC9417307 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature