Plasmonic random laser enabled artefact-free wide-field fluorescence bioimaging: uncovering finer cellular features.

ABSTRACT: Narrow bandwidth, high brightness, and spectral tunability are the unique properties of lasers that make them extremely desirable for fluorescence imaging applications. However, due to the high spatial coherence, conventional lasers are often incompatible for wide-field fluorescence imaging. The presence of parasitic artefacts under coherent illumination causes uneven excitation of fluorophores, which has a critical impact on the reliability, resolution, and efficiency of fluorescence imaging. Here, we demonstrate artefact-free wide-field fluorescence imaging with a bright and low threshold silver nanorod based plasmonic random laser, offering the capability to image finer cellular features with sub-micrometer resolution even in highly diffusive biological samples. A spatial resolution of

SUBMITTER: Gayathri R 

PROVIDER: S-EPMC9417316 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature