Machine learning-assisted discovery of growth decision elements by relating bacterial population dynamics to environmental diversity.

ABSTRACT: Microorganisms growing in their habitat constitute a complex system. How the individual constituents of the environment contribute to microbial growth remains largely unknown. The present study focused on the contribution of environmental constituents to population dynamics via a high-throughput assay and data-driven analysis of a wild-type Escherichia coli strain. A large dataset constituting a total of 12,828 bacterial growth curves with 966 medium combinations, which were composed of 44 pure chemical compounds, was acquired. Machine learning analysis of the big data relating the growth parameters to the medium combinations revealed that the decision-making components for bacterial growth were distinct among various growth phases, e.g., glucose, sulfate, and serine for maximum gro

SUBMITTER: Aida H 

PROVIDER: S-EPMC9417415 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature