A graphene-sandwiched DNA nano-system: regulation of intercalated doxorubicin for cellular localization.

ABSTRACT: Control of the sub-cellular localization of nanoparticles (NPs) with enhanced drug-loading capacity, employing graphene oxide (GO), iron oxide (Fe₃O₄) NPs and sandwiched deoxyribonucleic acid (DNA) bearing intercalated anticancer drug doxorubicin (DOX) has been investigated in this work. The nanosystems G-DNA-DOX-Fe₃O₄ and Fe₃O₄-DNA-DOX differentially influence serum protein binding and deliver DOX to lysosomal compartments of cervical cancer (HeLa) cells with enhanced retention. Stern-Volmer plots describing BSA adsorption on the nanosystems demonstrated the quenching constants, K _sv for G-DNA-DOX-Fe₃O₄ and Fe₃O₄-DNA-DOX (0.025 mL μg^-1 and 0.0103 mL μg

SUBMITTER: Nandi S 

PROVIDER: S-EPMC9417510 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature