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Tunable heat generation in nickel-substituted zinc ferrite nanoparticles for magnetic hyperthermia.

ABSTRACT: We report a high-performance magnetic nanoparticle as a hyperthermic agent under low applied field and frequency. CTAB (cetyltrimethylammonium bromide)-coated Ni _x Zn_1-x Fe₂O₄ nanoparticles of average particle size < 25 nm with various stoichiometric ratios were successfully synthesized using a co-precipitation technique. Characterization results indicate a close interaction of CTAB ions with the surface metal ions resulting in a cation distribution deviating from their equilibrium positions. Magnetic measurements were done at 300 K and 5 K using a superconducting quantum interference device. Saturation magnetization gradually increases with increasing substitution of Ni²⁺ ions with Zn²⁺ ions, attributed to the cation distribution and high super-exchange interaction between the A- and B-sites. The average size of the nanoparticles is estimated to be <10 nm with a magnetically dead layer (>1 nm @ 300 K), reflecting the effect of CTAB coating on the surface of the nanoparticles. The magnetocrystalline anisotropy (K _eff), obtained from the law of approach to saturation, is inversely proportional to the M _s value. The increasing incorporation of Ni²⁺ ions in the lattice system is found to influence various structural parameters, which is reflected in the magnetic performance of the nanoparticles. A specific absorption rate of 347 W g^-1 and intrinsic loss power of 4.6 nH m² kg^-1 was attained with a minimal concentration of 2 mg ml^-1 in a very short time period of 1.5 min in Ni_0.75Zn_0.25Fe₂O₄ nanoparticles.

SUBMITTER: Kahmei RDR

PROVIDER: S-EPMC9417590 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Tunable heat generation in nickel-substituted zinc ferrite nanoparticles for magnetic hyperthermia.

Kahmei R D Ralandinliu RDR Seal Papori P Borah J P JP

Nanoscale advances 20210810 18

We report a high-performance magnetic nanoparticle as a hyperthermic agent under low applied field and frequency. CTAB (cetyltrimethylammonium bromide)-coated Ni x Zn1-x Fe2O4 nanoparticles of average particle size < 25 nm with various stoichiometric ratios were successfully synthesized using a co-precipitation technique. Characterization results indicate a close interaction of CTAB ions with the surface metal ions resulting in a cation d ...[more]

PMID: 36132638

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Project description:Magnetically soft-soft MnFe2O4-Fe3O4 core-shell nanoparticles were synthesized through a seed-mediated method using the organometallic decomposition of metal acetyl acetonates. Two sets of core-shell nanoparticles (S1 and S2) of similar core sizes of 5.0 nm and different shell thicknesses (4.1 nm for S1 and 5.7 nm for S2) were obtained by changing the number of nucleating sites. Magnetic measurements were conducted on the nanoparticles at low and room temperatures to study the shell thickness and temperature dependence of the magnetic properties. Interestingly, both core-shell nanoparticles showed similar saturation magnetization, revealing the ineffective role of the shell thickness. In addition, the coercivity in both samples displayed similar temperature dependencies and magnitudes. Signatures of spin glass (SG) like behavior were observed from the field-cooled temperature-dependent magnetization measurements. It was suggested to be due to interface spin freezing. We observed a slight and non-monotonic temperature-dependent exchange bias in both samples with slightly higher values for S2. The effective magnetic anisotropy constant was calculated to be slightly larger in S2 than that in S1. The magnetothermal efficiency of the chitosan-coated nanoparticles was determined by measuring the specific absorption rate (SAR) under an alternating magnetic field (AMF) at 200-350 G field strengths and frequencies (495.25-167.30 kHz). The S2 nanoparticles displayed larger SAR values than the S1 nanoparticles at all field parameters. A maximum SAR value of 356.5 W/g was obtained for S2 at 495.25 kHz and 350 G for the 1 mg/mL nanoparticle concentration of ferrogel. We attributed this behavior to the larger interface SG regions in S2, which mediated the interaction between the core and shell and thus provided indirect exchange coupling between the core and shell phases. The SAR values of the core-shell nanoparticles roughly agreed with the predictions of the linear response theory. The concentration of the nanoparticles was found to affect heat conversion to a great extent. The in vitro treatment of the MDA-MB-231 human breast cancer cell line and HT-29 human colorectal cancer cell was conducted at selected frequencies and field strengths to evaluate the efficiency of the nanoparticles in killing cancer cells. The cellular cytotoxicity was estimated using flow cytometry and an MTT assay at 0 and 24 h after treatment with the AMF. The cells subjected to a 45 min treatment of the AMF (384.50 kHz and 350 G) showed a remarkable decrease in cell viability. The enhanced SAR values of the core-shell nanoparticles compared to the seeds with the most enhancement in S2 is an indication of the potential for tailoring nanoparticle structures and hence their magnetic properties for effective heat generation.

Dataset Information

Tunable heat generation in nickel-substituted zinc ferrite nanoparticles for magnetic hyperthermia.

Publications

Tunable heat generation in nickel-substituted zinc ferrite nanoparticles for magnetic hyperthermia.

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