NCX1 coupled with TRPC1 to promote gastric cancer via Ca²⁺/AKT/β-catenin pathway.

ABSTRACT: Plasma membrane Na⁺/Ca²⁺ exchanger 1 (NCX1) is a bidirectional ion transporter to operate in Ca²⁺ entry or exit modes, and TRPC1 is Ca²⁺-permeable channel. Both NCX1 and TRPC1 play critical roles in maintaining cytosolic free Ca²⁺ ([Ca²⁺]_cyt) homeostasis in mammalian cells. Although either TRPC1 channel or Ca²⁺ entry mode of NCX1 is implicated in some tumorigenesis, it has not been explored if a coordination of NCX1 and TRPC1 involves in the pathogenesis of H. pylori-associated human gastric cancer (GC). Here we found the protein expression of NCX1 was significantly enhanced in human GC specimens, which correlated with tumor progression and poor survival in GC patients. TRPC1 and NCX1 were parallelly en

SUBMITTER: Wan H 

PROVIDER: S-EPMC9418000 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature