Development of near-infrared sensitized core-shell-shell upconverting nanoparticles as pH-responsive probes.

ABSTRACT: Recently, the functionalization of nanoparticles, either within themselves or on the outer surface and its application in medicine, turned out to be the ultimate goal of nanotechnology. By providing these nanoparticles with chemical functional groups, one can force the nanoparticles to target the markers of the particular diseases or to measure the quantity and distribution of various intracellular species. In this paper, we report our development of a pH-responsive nanocomposite based on lanthanide-doped upconverting nanoparticles (UCNPs). Through multiphoton absorption and energy migration between spatially separated Nd³⁺, Yb³⁺, and Tm³⁺ in a three-layered NaYF₄ host coated with FITC (fluorescein-5-isothiocyanate), this nanocomposite can measur

SUBMITTER: Mahata MK 

PROVIDER: S-EPMC9418008 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature