Geometry-induced protein reorientation on the spikes of plasmonic gold nanostars.

ABSTRACT: Functionalized gold nanostars (AuStrs) are remarkable candidates for drug delivery, photothermal therapy and imaging due to their large surface area to volume ratio and plasmonic properties. In this study, we address the challenge of achieving therapeutically controlled dosing using these high aspect ratio nanoparticle vectors by tailoring the nanostar loading area and protein conformation. We synthesized a library of different Au nanostars with varied geometries for potential biomedical applications. The Au nanostars were subsequently coated with different amounts of transferrin (Tf) and a novel depletion method was devised to measure the amount of Tf bound to the surface of the nanostructures. This methodology allowed us to show that coating thickness could be controllably varied and mou

SUBMITTER: Lopes Rodrigues R 

PROVIDER: S-EPMC9418033 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature