AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death.

ABSTRACT: AMPK has been reported to facilitate hypoxic pulmonary vasoconstriction but, paradoxically, its deficiency precipitates pulmonary hypertension. Here we show that AMPK-α1/α2 deficiency in smooth muscles promotes persistent pulmonary hypertension of the new-born. Accordingly, dual AMPK-α1/α2 deletion in smooth muscles causes premature death of mice after birth, associated with increased muscularisation and remodeling throughout the pulmonary arterial tree, reduced alveolar numbers and alveolar membrane thickening, but with no oedema. Spectral Doppler ultrasound indicates pulmonary hypertension and attenuated hypoxic pulmonary vasoconstriction. Age-dependent right ventricular pressure elevation, dilation and reduced cardiac output was also evident. K_V1.5 potassium currents of pulmo

SUBMITTER: Moral-Sanz J 

PROVIDER: S-EPMC9418192 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature