Revisiting the factors influencing the magnetic resonance contrast of Gd₂O₃ nanoparticles.

ABSTRACT: Gadolinium oxide nanoparticles (GONs) have the potential to be one of the best candidates for the contrast agents of magnetic resonance imaging. Even though the influence of parameters on the relaxation has been substantially demonstrated, the variation of the r ₁ of GONs with a similar structure and surface chemistry implied our limited understanding. We herein synthesized GONs with adjustable size, shape, and crystallinity, modified them with a series of molecules with different acidities, and recorded their r ₁ values and imaging contrast. Our results showed that the isoelectric point could be regarded as an indicator of the relaxation covering the influence of both surface modification and size, which highlighted the impact of protons dissociated fro

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9418219 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature