Spatiotemporal multi-scale modeling of radiopharmaceutical distributions in vascularized solid tumors.

ABSTRACT: We present comprehensive mathematical modeling of radiopharmaceutical spatiotemporal distributions within vascularized solid tumors. The novelty of the presented model is at mathematical level. From the mathematical viewpoint, we provide a general modeling framework for the process of radiopharmaceutical distribution in the tumor microenvironment to enable an analysis of the effect of various tumor-related parameters on the distribution of different radiopharmaceuticals. We argue that partial differential equations (PDEs), beyond conventional methods, including ODE-based kinetic compartment modeling, can be used to evaluate radiopharmaceutical distribution in both time and space. In addition, we consider the spatially-variable dynamic structure of tumor microvascular networks to simulate b

SUBMITTER: Kiani Shahvandi M 

PROVIDER: S-EPMC9418261 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature