Sex-specific genetic association between psychiatric disorders and cognition, behavior and brain imaging in children and adults.

ABSTRACT: Although there are pronounced sex differences for psychiatric disorders, relatively little has been published on the heterogeneity of sex-specific genetic effects for these traits until very recently for adults. Much less is known about children because most psychiatric disorders will not manifest until later in life and existing studies for children on psychiatric traits such as cognitive functions are underpowered. We used results from publicly available genome-wide association studies for six psychiatric disorders and individual-level data from the Adolescent Brain Cognitive Development (ABCD) study and the UK Biobank (UKB) study to evaluate the associations between the predicted polygenic risk scores (PRS) of these six disorders and observed cognitive functions, behavioral and brain im

SUBMITTER: Gui Y 

PROVIDER: S-EPMC9418275 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature