A Systematic Review and Meta-Analysis on the Effects of Exercise on the Endocannabinoid System.

ABSTRACT: Introduction: The endocannabinoid (eCB) system plays a key role in maintaining homeostasis, including the regulation of metabolism and stress responses. Chronic stress may blunt eCB signaling, and disruptions in eCB signaling have been linked to stress-related psychiatric disorders and physical health conditions, including anxiety, depression, post-traumatic stress disorder (PTSD), diabetes, and obesity. Pharmacological and nonpharmacological behavioral interventions (e.g., exercise) that target the eCB system may be promising therapeutic approaches for the prevention and treatment of stress-related diseases. In this study, we perform a systematic review and the first meta-analysis to examine the impact of exercise on circulating eCB concentrations. Materials and Methods: We

SUBMITTER: Desai S 

PROVIDER: S-EPMC9418357 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature