Bioinspired photo-crosslinkable self-assembling peptides with pH-switchable "on-off" luminescence.

ABSTRACT: Significant progress has been made in peptide self-assembly over the past two decades; however, the in situ cross-linking of self-assembling peptides yielding better performing nanomaterials is still in its infancy. Indeed, self-assembling peptides (SAPs), relying only on non-covalent interactions, are mechanically unstable and susceptible to solvent erosion, greatly hindering their practical application. Herein, drawing inspiration from the biological functions of tyrosine, we present a photo-cross-linking approach for the in situ cross-linking of a tyrosine-containing LDLK12 SAP. This method is based on the ruthenium-complex-catalyzed conversion of tyrosine to dityrosine upon light irradiation. We observed a stable formation of dityrosine cross-linking starting from 5 minut

SUBMITTER: Pugliese R 

PROVIDER: S-EPMC9418485 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature