The burden of non-alcoholic steatohepatitis: A systematic review of health-related quality of life and patient-reported outcomes.

ABSTRACT:

Background & aims

Non-alcoholic steatohepatitis (NASH) is associated with increased mortality and a high clinical burden. NASH adversely impacts patients' health-related quality of life (HRQoL), but published data on the humanistic burden of disease are limited. This review aimed to summarise and critically evaluate studies reporting HRQoL or patient-reported outcomes (PROs) in populations with NASH and identify key gaps for further research.

Methods

Medline, EMBASE, the Cochrane Library and PsycINFO were searched for English-language publications published from 2010 to 2021 that reported HRQoL/PRO outcomes of a population or subpopulation with NASH.

Results

Twenty-five publications covering 23 unique studies were identified. Overall, the data showed a substantial imp

SUBMITTER: Younossi Z 

PROVIDER: S-EPMC9418497 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature